The Structure and Functions of Glucocerebrosidase (1221 words, 8 pages)
Glucocerebrosidase is an enzyme of clinical importance that causes Gaucher disease when insufficient enzyme is present in the lysosome. The enzyme cleaves the beta glucosidic linkage of glucocerebroside (glucosylceramide). Accumulation of glucocerebroside causes bruising, anemia, skeletal lesions, and neurological complications. This disease is genetic, and mutations in both copies are ...
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